Coumadin, Heparin, Antidotes and Lab Values for Drugs

Here are what lab test you use for blood thinners effectiveness:
Protamine sulfate: antidote for heparin (use is when patient’s aPTT is very high);  it works quickly.
Easy way to remember is – HPaPTT (H for Heparin, P for Protamine the antidote, aPTT for the lab test used)

Vitamin K: antidote for coumadin (uses PT/INR); both work slowly.
Easy way to remember is – CKPT/INR (C for Coumadin, K for vitamin k, PT/INR for the lab testing conducted)

Partial thromboplastin time or PTT – 60 to 70 seconds

APTT or Activated Partial Thrombin time – 30 to 40 seconds

A longer than normal ptt or aptt can be caused by low level of one of the blood clotting factors or another substance needed to clot blood or by bleeding disorders, liver disease, kidney disease, or use of blood thinners.

And now here are the Normal Therapeutic Range for the following important drugs:
Digoxin 0.8 – 2 nanogram/ml.
Digoxin is a cardiac glycoside, it increases the cardiac output not by making heart beat faster but my strengthening the contraction and thus more blood flow results. Used in CHF. Used in treating anti-arrhythmic effects.

Gentamicin 5 – 10 microgram/ml.

Dilantin 10 – 20 microgram/ml.
Dilantin is an antiepileptic drug used in treating various types of seizures.


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